OMCA is comprised of four Centers that are described in detail below:

Center for Administration and Business Operations

The Center for Administration and Business Operations (CABO) provides strategic decision making and ongoing infrastructure support to advance OMCA's mission and goals. The staff in CABO oversee and provide executive support, perform financial management and business analysis, develop human resource structure and support, optimize technology opportunities and manage implementation, facility rentals, the OMCA Store and online retail, and ensure a secure and efficient environment by maintaining, troubleshooting and strategizing optimal use of the Museum's facilities and gardens.

 Center for Audience and Civic Engagement

The Center for Audience and Civic Engagement (CACE) integrates audience development, external communications, learning initiatives, community partnerships, visitor services, and public programs to engage the public in multiple ways. The staff in CACE ensure the highest standards for visitor experience, community engagement, and participation on-site, online, and off-site.

Center for Experience Development and Collections

The Center for Experience Development and Collections (CEDC) brings together curatorial content expertise in California art, history, and natural sciences with visitor-centered interpretative approaches and visitor research evaluation. CEDC staff advance interdisciplinary connections between disciplines, link contemporary issues with historic trends, strive to increase access to the collections, both physical and digital, for research, licensing, and public use, and align content delivery goals with visitor experience strategies through a range of platforms including exhibitions, collection presentations, public programming, on-line activities, and publications. This Center also coordinates all production functions for OMCA, including professional exhibition and graphic design, preparation and installation, media development and production, orchestrate logistics and maintain systems for documentation, security, and access; monitor storage and display environments, conduct material analysis and conservation treatments; and coordination with other Centers in managing exhibition development processes.

Center for Philanthropy and Institutional Advancement

The Center for Philanthropy and Institutional Advancement (CPIA) cultivates a vibrant mix of contributed and earned income to support OMCA. Working with the Board of Trustees and staff across other centers, the CPIA staff manages all fundraising, membership, special events, and develops new enterprise activities.